銆€銆€銆愭憳瑕併€�2015骞村煼(zh铆)妤�(y猫)钘ュ斧钘ュ(xu茅)灏堟キ(y猫)鐭ヨ瓨(sh铆)涓€鐢卞師渚�(l谩i)钘ョ悊瀛�(xu茅)鍜岃棩鐗╁垎鏋愬叐鍊�(g猫)灏忕鐩敼鐐轰互钘ュ姂瀛�(xu茅)鍜岃棩鐗╁寲瀛�(xu茅)鐐轰富锛屽皯閮ㄥ垎娑夊強钘ョ悊瀛�(xu茅)鍜岃棩鐗╁垎鏋愮殑澶氬(xu茅)绉戠殑缍滃悎鐭ヨ瓨(sh铆)銆傜偤骞姪澶у鏇村ソ鐨勫京(f霉)缈�(x铆)锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍￠啱(y墨)瀛�(xu茅)鑰冭│缍�(w菐ng)鐗规暣鐞�2015鍩�(zh铆)妤�(y猫)钘ュ斧钘ュ姂瀛�(xu茅)绗崄鍏珷钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鍏�(n猫i)閮ㄨ瑳缇瑗胯棩瀛�(xu茅)灏堟キ(y猫)鐭ヨ瓨(sh铆)涓€绔犵瘈(ji茅)寰�(f霉)缈�(x铆)绮鹃伕渚涘ぇ瀹跺弮鑰�锛屽笇鏈涘皪(du矛)澶у鍌欒€冩湁骞姪銆�

銆€銆€鐩搁棞(gu膩n)鎺ㄨ枽锛�2015鍩�(zh铆)妤�(y猫)瑗胯棩甯€冭│钘ュ姂瀛�(xu茅)鍏�(n猫i)閮ㄨ瑳缇╁尟绺絖钘ュ(xu茅)灏堟キ(y猫)鐭ヨ瓨(sh铆)涓€钘ュ姂瀛�(xu茅)绔犵瘈(ji茅)寰�(f霉)缈�(x铆)绮鹃伕鍖附

銆€銆€瑕侀粸(di菐n)鍥為¨锛�

銆€銆€1.甯哥敤琛�(sh霉)瑾�(y菙)锛氶殧瀹ゆā鍨嬨€佹秷闄ら€熺巼甯告暩(sh霉)銆佺敓鐗╁崐琛版湡銆佺附娓呴櫎鐜�

銆€銆€2.5绲凜-t鍏紡锛�?ji菐n)闂し锛拌洣?澶�)鍔戦噺闈滄敞銆侀潨婊�銆佽绠″绲﹁棩

銆€銆€3.鐢熺墿鍒╃敤搴�

銆€銆€涓€銆佸父鐢ㄨ(sh霉)瑾�(y菙)

銆€銆€1.钘ョ墿鍕�(d貌ng)鍔涘(xu茅)锛氱爺绌惰棩鐗╅珨鍏�(n猫i)钘ラ噺闅ㄦ檪(sh铆)闁撹畩鍖栬(gu墨)寰�銆�

銆€銆€2.钘ョ墿杞�(zhu菐n)閬�(y霉n)(鍚告敹銆佸垎甯�銆佹帓娉�)鐨勯€熷害閬�(gu貌)绋�

銆€銆€(1)涓€绱�(j铆)閫熷害閬�(gu貌)绋嬶細閫熷害鑸囪棩閲忔垨琛€钘ユ績搴︽垚姝ｆ瘮

銆€銆€(2)闆剁礆(j铆)閫熷害閬�(gu貌)绋�(闆剁礆(j铆)鍕�(d貌ng)鍔涘(xu茅)閬�(gu貌)绋�)锛氶€熷害鎭掑畾锛岃垏琛€钘ユ績搴︾劇(w煤)闂�(gu膩n)——鎭掗€熼潨婊寸殑绲﹁棩閫熷害銆佹帶閲嬪埗鍔戣棩鐗╅噵鏀鹃€熷害

銆€銆€(3)鍙楅叾娲诲姏闄愬埗鐨勯€熷害閬�(gu貌)绋�(绫虫皬鍕�(d貌ng)鍔涘(xu茅)閬�(gu貌)绋�)锛氳棩鐗╂績搴﹂珮鍑虹従(xi脿n)閰舵椿鍔涢＝鍜屾檪(sh铆)鐨勯€熷害閬�(gu貌)绋�

銆€銆€3.闅斿妯″瀷

銆€銆€钘ョ墿鐨勯珨鍏�(n猫i)閬�(gu貌)绋嬩竴鑸寘鎷惛鏀�銆佸垎甯冦€佷唬璎�(鐢熺墿杞�(zhu菐n)鍖�)鍜屾帓娉勯亷(gu貌)绋�銆傜偤浜嗗畾閲忓湴鐮旂┒閫欎簺閬�(gu貌)绋嬬殑璁婂寲锛岄渶寤虹珛鏁�(sh霉)瀛�(xu茅)妯″瀷锛岀ū鍏剁偤鍕�(d貌ng)鍔涘(xu茅)妯″瀷锛岃€岄殧瀹ゆā鍨嬫槸鏈€甯哥敤鐨勬ā鍨�銆�

銆€銆€鍠銆佷簩瀹ゃ€佸瀹�

銆€銆€浜屽锛氫腑澶(琛€娑�+蹇�銆佽偤銆佽倽銆佽厧)锛岃棩鐗╁湪涓ぎ瀹よ繀閫熼仈(d谩)鍒板垎甯冨钩琛�;鍛ㄩ倞瀹�(鑲岃倝銆佺毊鑶氱瓑)锛岃棩鐗╁湪鍛ㄩ倞瀹ゅ垎甯冭純鎱�銆�

銆€銆€閰嶄紞閬告搰椤�

銆€銆€A.钘ョ墿鍕�(d貌ng)鍔涘(xu茅)

銆€銆€B.鐢熺墿鍒╃敤搴�

銆€銆€C.鑵歌倽寰挵(hu谩n)

銆€銆€D.鍠妯″瀷钘ョ墿

銆€銆€E.琛ㄨ鍒嗗竷瀹圭⿳

銆€銆€1.鑶芥眮涓帓鍑虹殑钘ョ墿鎴栦唬璎濈墿锛屽湪灏忚吀杞�(zhu菐n)閬�(y霉n)鏈熼枔閲嶅惛鏀惰€岃繑鍥為杸(m茅n)闈滆剤鐨勭従(xi脿n)璞℃槸

銆€銆€銆愭纰虹瓟妗堛€慍

銆€銆€2.鍒跺姂涓棩鐗╅€�(j矛n)鍏ラ珨寰挵(hu谩n)鐨勭浉灏�(du矛)鏁�(sh霉)閲忓拰鐩稿皪(du矛)閫熷害鏄�

銆€銆€銆愭纰虹瓟妗堛€態

銆€銆€3.閫�(j矛n)鍏ラ珨寰挵(hu谩n)鍚�锛岃繀閫熷垎甯冧簬鍚勭祫绻斿櫒瀹樹腑锛屽苟绔嬪嵆閬�(d谩)鍒板嫊(d貌ng)鎱�(t脿i)鍒嗗竷骞宠　鐨勮棩鐗╂槸

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€4.閲囩敤鍕�(d貌ng)鍔涘(xu茅)鍩烘湰鍘熺悊鍜屾暩(sh霉)瀛�(xu茅)铏曠悊鏂规硶锛岀爺绌惰棩鐗╅珨鍏�(n猫i)鐨勮棩閲忛毃鏅�(sh铆)闁撹畩鍖栬(gu墨)寰嬬殑绉戝(xu茅)鏄�

銆€銆€銆愭纰虹瓟妗堛€慉

銆€銆€钘ョ墿鍕�(d貌ng)鍔涘(xu茅)绲勭箶绲�(ji茅)妲�(g貌u)鍦�

銆€銆€4.绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�(鍧績搴�銆丆SS)

銆€銆€鍦ㄩ潨鑴堟淮娉ㄩ枊(k膩i)濮嬬殑涓€娈垫檪(sh铆)闁撳収(n猫i)锛岃钘ユ績搴︿笂鍗�锛岀辜鑰岄€愭几娓涙參锛岀劧鍚庤定杩戜簬涓€鍊�(g猫)鎭掑畾姘村钩锛屽湪閫欑ó鐙€鎱�(t脿i)涓�锛岄珨鍏�(n猫i)钘ョ墿鐨勬秷闄ら€熷害绛変簬钘ョ墿鐨勮几鍏ラ€熷害銆�

銆€銆€5.閬�(d谩)绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑鍒�?j菒n)?sh霉)(fss)

銆€銆€fss锛歵鏅�(sh铆)闁撻珨鍏�(n猫i)琛€钘ユ績搴﹁垏閬�(d谩)绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︿箣姣斿€�

銆€銆€n=-3.323lg(1-fss)

銆€銆€鍏紡涓殑n鐐哄崐琛版湡鐨勫€�(g猫)鏁�(sh霉)銆�

銆€銆€涓婂紡瑾�(shu艒)鏄庝笉璜栦綍绋棩鍝侊紝閬�(d谩)鍒扮┅(w臎n)鎱�(t脿i)鐩稿悓鍒�?j菒n)?sh霉)锛屾墍闇€鍗婅“鏈熺殑鍊�(g猫)鏁�(sh霉)鐩稿悓锛岄仈(d谩)90%锝�99%闇€3.3锝�6.64鍊�(g猫)鍗婅“鏈熸檪(sh铆)闁�銆�

銆€銆€n=1→50%

銆€銆€n=3.32→90%

銆€銆€n=6.64→99%

銆€銆€n=10→99.9%

銆€銆€6.甯哥敤鍙冩暩(sh霉)

銆€銆€1)娑堥櫎閫熷害甯告暩(sh霉) (h-1銆乨-1)

銆€銆€(浠ｈ瑵+鎺掓硠)k=kb+ke+kbi+klu+ ……

銆€銆€2)鐢熺墿鍗婅“鏈�(t1/2)

銆€銆€楂斿収(n猫i)钘ラ噺鎴栬钘ユ績搴︽秷闄や竴鍗婃墍闇€瑕佺殑鏅�(sh铆)闁�銆傝　閲忎竴绋棩鐗╁緸楂斿収(n猫i)娑堥櫎閫熷害鐨勫弮鏁�(sh霉)銆�

銆€銆€t1/2 =0.693/k

銆€銆€t1/2<1h 妤电煭鍗婅“鏈熻棩鐗� 銆€銆€t1/21锝�4h绋辩煭鍗婅“鏈熻棩鐗�

銆€銆€t1/24锝�81h 涓瓑鍗婅“鏈熻棩鐗� 銆€銆€t1/28锝�24绋遍暦(zh菐ng)鍗婅“鏈熻棩鐗�

銆€銆€t1/2>24h 妤甸暦(zh菐ng)鍗婅“鏈熻棩鐗�

銆€銆€娑堥櫎閫斿緫鏈夌稉(j墨ng)鑵庤嚐鎺掓硠ke銆佽喗姹佹帓娉刱bi銆佽倽鑷熶唬璎漦b鍙婅偤閮ㄥ懠鍚告帓娉刱lu

銆€銆€鏈€浣抽伕鎿囬

銆€銆€宸茬煡鍙ｆ湇鑲濊嚐棣栭亷(gu貌)浣滅敤寰堝ぇ鐨勮棩鐗�锛屾敼鐢ㄨ倢鑲夋敞灏勫悗

銆€銆€A.t1/2澧炲姞锛岀敓鐗╁埄鐢ㄥ害涔熷鍔�

銆€銆€B.t1/2娓涘皯锛岀敓鐗╁埄鐢ㄥ害涔熸笡灏�

銆€銆€C.t1/2鍜岀敓鐗╁埄鐢ㄥ害鐨嗕笉璁婂寲

銆€銆€D.t1/2涓嶈畩锛岀敓鐗╁埄鐢ㄥ害澧炲姞

銆€銆€E.t1/2涓嶈畩锛岀敓鐗╁埄鐢ㄥ害娓涘皯

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€鏈€浣抽伕鎿囬

銆€銆€娓�(c猫)寰楀埄澶氬崱鍥犵殑娑堥櫎閫熷害甯告暩(sh霉)鐐�0.3465h-1锛屽墖瀹冪殑鐢熺墿鍗婅“鏈�

銆€銆€A.4h

銆€銆€B.1.5h

銆€銆€C.2.0h

銆€銆€D.0.693h

銆€銆€E.1h

銆€銆€銆愭纰虹瓟妗堛€慍

銆€銆€銆愮瓟妗堣В鏋愩€憈1/2=0.693/k

銆€銆€3)娓呴櫎鐜�(楂旂⿳/鏅�(sh铆)闁�)

銆€銆€姗�(j墨)楂旀垨姗�(j墨)楂旂殑鏌愪簺娑堥櫎鍣ㄥ畼銆佺祫绻斿湪鍠綅鏅�(sh铆)闁撳収(n猫i)娓呴櫎鎺夌浉鐣�(d膩ng)浜庡灏戦珨绌嶇殑娴佺稉(j墨ng)琛€娑蹭腑鐨勮棩鐗�

銆€銆€Cl=(-dx/dt)/C=kV

銆€銆€浜屻€佸柈瀹�-闈滄敞

銆€銆€琛€钘ユ績搴︽硶銆€銆€鍠姂闈滄敞鏄熀绀�(ch菙)锛宔璁婂皪(du矛)鏁�(sh霉)鎵緇g

銆€銆€闈滆剤娉ㄥ皠绲﹁棩锛岀敱浜庤棩鐗╁湪楂斿収(n猫i)鍙湁娑堥櫎(鐒�(w煤)鍚告敹閬�(gu貌)绋�)閬�(gu貌)绋�锛岃€屾秷闄ら亷(gu貌)绋嬫寜涓€绱�(j铆)閫熷害閬�(gu貌)绋嬮€�(j矛n)琛屻€傚嵆钘ョ墿娑堥櫎閫熷害鑸囬珨鍏�(n猫i)钘ラ噺鐨勪竴娆℃柟鎴愭姣�锛屽叾鍕�(d貌ng)鍔涘(xu茅)鏂圭▼鐐猴細

銆€銆€C=C0 e-kt

銆€銆€lgX=(-kt/2.303)+lgX0

銆€銆€X0銆乆锛氳棩鐗╁垵濮嬮噺銆乼鏅�(sh铆)鍒荤殑閲�

銆€銆€lgC=(-kt/2.303)+lgC0

銆€銆€C0銆丆锛氳棩鐗╁垵婵冨害銆乼鏅�(sh铆)鍒昏棩鐗╂績搴�

銆€銆€涓�銆佸柈瀹�-闈滄淮

銆€銆€闈滄淮瑕佹壘K0鍊硷紝婊存敞閫熷害鍒ュ繕瑷�

銆€銆€鍥�銆佸柈瀹�-琛€绠″绲﹁棩(鍙ｆ湇銆佽倢鍏�(n猫i)銆佺毊涓�)

銆€銆€琛€绠″绲﹁棩鎵綟锛屽惛鏀跺垎?j菒n)?sh霉)璺戜笉浜�

銆€銆€浜斻€佸鍔戦噺绲﹁棩——澶氬姂閲忎笉鐢ㄦ€�锛屽叕寮忛夯鐓╀笉闆ｈ

銆€銆€1.闈滆剤娉ㄥ皠

銆€銆€闈滄敞绌�(w臎n)鎱�(t脿i)2鍏紡锛岄枔闅旂郸钘ユ壘τ鍊�

銆€銆€鏈€浣抽伕鎿囬

銆€銆€绲︽煇鎮ｈ€呴潨鑴堟敞灏�(鎺ㄦ敞)鏌愯棩锛屽凡鐭�?ji菐ng)鈹濈笓0=500mg锛孷=101锛宬=-0.1h-1,τ=10h锛岃┎鎮ｈ€呯郸钘ラ仈(d谩)绌�(w臎n)鎱�(t脿i)鍚庣殑骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸

銆€銆€A.0.05mg/l

銆€銆€B.0.5mg/l

銆€銆€C.5mg/l

銆€銆€D.50mg/l

銆€銆€E.500mg/l

銆€銆€銆愭纰虹瓟妗堛€慐

銆€銆€鏈€浣抽伕鎿囬

銆€銆€闈滄敞鏌愬柈瀹ゆā鍨嬭棩鐗╁妯″瀷钘ョ墿锛屾瘡10灏忔檪(sh铆)绲﹁棩涓€娆★紝宸辩煡瑭茶棩V=10L锛孹0=500mg锛孠=0.1h-1锛屽叾骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸

銆€銆€A.5mg/L

銆€銆€B.50mg/L

銆€銆€C.500mg/L

銆€銆€D.5000mg/L

銆€銆€E.50000mg/L

銆€銆€銆愭纰虹瓟妗堛€態

銆€銆€澶氬姂閲忕郸钘ユ槸鑷ㄥ簥甯哥敤鐨勭郸钘ユ柟寮�锛屽鏁�(sh霉)钘ョ墿闇€瑕佹寜鐓т竴瀹氱殑鍔戦噺銆佷竴瀹氱殑鏅�(sh铆)闁撻枔闅�锛屽娆＄郸钘ユ墠鑳介仈(d谩)鍒伴爯(y霉)鏈熺殑琛€钘ユ績搴�锛屽苟淇濇寔鍦ㄤ竴瀹氱殑鏈夋晥琛€钘ユ績搴﹁寖鍦嶅収(n猫i)銆傞毃钁楀娆＄郸钘ワ紝楂斿収(n猫i)钘ラ噺涓嶆柗澧炲姞锛屽悓鏅�(sh铆)娑堥櫎涔熺浉鎳�(y墨ng)鍔犲揩锛岀稉(j墨ng)閬�(gu貌)涓€娈垫檪(sh铆)闁撳悗閬�(d谩)鍒扮┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︺€�

銆€銆€2.琛€绠″绲﹁棩

銆€銆€琛€绠″涔�2鍏紡锛屽叕寮忔渶闀�(zh菐ng)鏈€濂借

銆€銆€n娆＄郸钘ュ悗锛�

銆€銆€鏈€浣抽伕鎿囬

銆€銆€闂�(gu膩n)浜庡柈瀹ら潨鑴堟淮娉ㄧ郸钘ョ殑閷�(cu貌)瑾よ〃杩版槸

銆€銆€A.k0鏄浂绱�(j铆)婊存敞閫熷害

銆€銆€B.绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴ss鑸囨淮娉ㄩ€熷害k0鎴愭姣�

銆€銆€C.绌�(w臎n)鎱�(t脿i)鏅�(sh铆)楂斿収(n猫i)钘ラ噺鎴栬钘ユ績搴︽亽瀹氫笉璁�

銆€銆€D.娆叉淮娉ㄩ仈(d谩)绌�(w臎n)鎱�(t脿i)婵冨害鐨�99%锛岄渶婊存敞3.32鍊�(g猫)鍗婅“鏈�

銆€銆€E.闈滄淮鍓嶅悓鏅�(sh铆)闈滄敞涓€鍊�(g猫)k0/k鐨勮矤(f霉)鑽峰姂閲忥紝鍙娇琛€钘ユ績搴︿竴闁�(k膩i)濮嬪氨閬�(d谩)绌�(w臎n)鎱�(t脿i)

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€鏈€浣抽伕鎿囬

銆€銆€闂�(gu膩n)浜庡柈瀹ゆā鍨嬪柈鍔戦噺琛€绠″绲﹁棩鐨勯尟(cu貌)瑾よ〃杩版槸

銆€銆€A.C-t鍏紡鐐洪洐鎸囨暩(sh霉)鏂圭▼

銆€銆€B.閬�(d谩)宄版檪(sh铆)闁撹垏绲﹁棩鍔戦噺X0鎴愭姣�

銆€銆€C.宄版績搴﹁垏绲﹁棩鍔戦噺X0鎴愭姣�

銆€銆€D.鏇茬窔涓嬮潰绌嶈垏绲﹁棩鍔戦噺X0鎴愭姣�

銆€銆€E.鐢辨畼鏁�(sh霉)娉曞彲姹傝棩鐗╃殑鍚告敹閫熷害甯告暩(sh霉)Ka

銆€銆€銆愭纰虹瓟妗堛€態——tmax鐢眐a銆乲姹哄畾锛岃垏鍔戦噺X0鐒�(w煤)闂�(gu膩n)

銆€銆€閰嶄紞閬告搰椤�

銆€銆€A.1gC=(-k/2.303)t+lgC0

銆€銆€B.t0.9=C0/10k 銆€銆€C.C-C0=-kt

銆€銆€D.t0.9=0.1054/k 銆€銆€E.tl/2=0.693/k

銆€銆€1.闆剁礆(j铆)鍙嶆噳(y墨ng)鏈夋晥鏈熻▓(j矛)绠楀叕寮忔槸

銆€銆€銆愭纰虹瓟妗堛€態

銆€銆€2.涓€绱�(j铆)鍙嶆噳(y墨ng)閫熷害鏂圭▼寮忔槸

銆€銆€銆愭纰虹瓟妗堛€慉

銆€銆€3.涓€绱�(j铆)鍙嶆噳(y墨ng)鏈夋晥鏈熻▓(j矛)绠楀叕寮忔槸

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€4.涓€绱�(j铆)鍙嶆噳(y墨ng)鍗婅“鏈熻▓(j矛)绠楀叕寮忔槸

銆€銆€銆愭纰虹瓟妗堛€慐

銆€銆€閰嶄紞閬告搰椤�

銆€銆€1.鍠妯″瀷鍠姂閲忛潨鑴堟敞灏勭郸钘�锛岃钘ユ績搴﹀叕寮忕偤

銆€銆€銆愭纰虹瓟妗堛€態

銆€銆€2.鍠妯″瀷鍠姂閲忛潨鑴堟淮娉ㄧ郸钘ワ紝琛€钘ユ績搴﹀叕寮忕偤

銆€銆€銆愭纰虹瓟妗堛€慉

銆€銆€3.鍠妯″瀷鍠姂閲忚绠″绲﹁棩锛岃钘ユ績搴﹀叕寮忕偤

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€4.鍠妯″瀷澶氬姂閲忛潨鑴堟敞灏勭郸钘ワ紝閬�(d谩)绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴﹀叕寮忕偤

銆€銆€銆愭纰虹瓟妗堛€慍

銆€銆€鍠妯″瀷(5绋郸钘ユā寮�锛�9鍊�(g猫)C-t鍏紡)

銆€銆€鈽呰儗瑷樻妧宸р槄

銆€銆€鍠姂闈滄敞鏄熀绀�(ch菙)锛宔璁婂皪(du矛)鏁�(sh霉)鎵緇g

銆€銆€闈滄淮瑕佹壘K0鍊�锛屾淮娉ㄩ€熷害鍒ュ繕瑷�

銆€銆€琛€绠″绲﹁棩鎵綟锛屽惛鏀跺垎?j菒n)?sh霉)璺戜笉浜�

銆€銆€澶氬姂閲忎笉鐢ㄦ€�锛屽叕寮忛夯鐓╀笉闆ｈ

銆€銆€闈滄敞绌�(w臎n)鎱�(t脿i)2鍏紡锛岄枔闅旂郸钘ユ壘τ鍊�

銆€銆€琛€绠″涔�2鍏紡锛屽叕寮忔渶闀�(zh菐ng)鏈€濂借

銆€銆€閰嶄紞閬告搰椤�

銆€銆€A. pKa-pH=1g(Cu/Ci)

銆€銆€B. pKa-pH=1g(Ci/Cu)

銆€銆€1.琛ㄧず寮遍吀鍚告敹鐨凥enderson-Hasselbalch鐨勬柟绋嬪紡鏄�

銆€銆€銆愭纰虹瓟妗堛€慉

銆€銆€2.琛ㄧず寮卞牽鍚告敹鐨凥enderson-Hasselbalch鐨勬柟绋嬪紡鏄�

銆€銆€銆愭纰虹瓟妗堛€態

銆€銆€3.Noyes-whitney鏂圭▼寮忔槸

銆€銆€銆愭纰虹瓟妗堛€慍

銆€銆€4.鑳冩帓绌洪€熺巼鍏紡鏄�

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€鏈€浣抽伕鎿囬

銆€銆€鍦伴珮杈涚殑鍗婅“鏈熺偤40.8h锛屽湪楂斿収(n猫i)姣忓ぉ娑堥櫎鍓╀綑閲忕櫨鍒嗕箣骞�

銆€銆€A.35.88%

銆€銆€B.40.76%

銆€銆€C.66.52%

銆€銆€D.29.41%

銆€銆€E.87.67%

銆€銆€銆愭纰虹瓟妗堛€慉

銆€銆€銆愮瓟妗堣В鏋愩€戝埄鐢ㄥ叕寮弔1/2=0.693/K锛�

銆€銆€k=0.693/t1/2=0.693/40.8=0.0169×24=0.4056

銆€銆€Ct=C0 e-kt

銆€銆€Ct/C0=1/e0.4056≈0.66

銆€銆€鏈€浣抽伕鎿囬

銆€銆€鍋囪ō(sh猫)钘ョ墿娑堥櫎绗﹀悎涓€绱�(j铆)鍕�(d貌ng)鍔涘(xu茅)閬�(gu貌)绋�锛岀稉(j墨ng)澶氬皯鍊�(g猫)t1/2钘ョ墿娑堥櫎99.9%

銆€銆€A.4t1/2

銆€銆€B.6t1/2

銆€銆€C.8t1/2

銆€銆€D.10t1/2

銆€銆€E.12t1/2

銆€銆€銆愭纰虹瓟妗堛€慏

銆€銆€鍏€佺敓鐗╁埄鐢ㄥ害

銆€銆€琛€绠″绲﹁棩鐢ㄨ棩鍔戦噺涓€�(j矛n)鍏ラ珨寰挵(hu谩n)鐨勭浉灏�(du矛)鏁�(sh霉)閲忚垏鍦ㄥぇ寰挵(hu谩n)鍑虹従(xi脿n)鐨勭浉灏�(du矛)閫熺巼銆傚嵆钘ョ墿鍚告敹閫�(j矛n)鍏ヨ娑插惊鐠�(hu谩n)鐨勭▼搴﹁垏閫熷害銆�

銆€銆€鐢熺墿鍒╃敤绋嬪害锛氬惛鏀剁殑澶氬皯——C-t鏇茬窔涓嬮潰绌�(AUC)

銆€銆€鐢熺墿鍒╃敤閫熷害锛氬惛鏀剁殑蹇參——閬�(d谩)宄版檪(sh铆)闁� (tmax)

銆€銆€鑵虫敞T鑸嘡鍒嗗垾浠ｈ〃瑭﹂(y脿n)鍒跺姂鑸囧弮姣斿埗鍔戯紝iv浠ｈ〃闈滆剤娉ㄥ皠鍔�銆�

銆€銆€琛€钘ユ績搴︽檪(sh铆)闁撴洸绶�

銆€銆€鏈€浣抽伕鎿囬

銆€銆€闂�(gu膩n)浜庣敓鐗╁埄鐢ㄥ害鍜岀敓鐗╃瓑鏁堟€ц│椹�(y脿n)瑷�(sh猫)瑷�(j矛)鐨勯尟(cu貌)瑾よ〃杩版槸

銆€銆€A.鐮旂┒灏�(du矛)璞＄殑閬告搰姊濅欢鐐猴細骞撮健涓€鑸偤18锝�40姝诧紝楂旈噸鐐烘(bi膩o)婧�(zh菙n)楂旈噸±10%鐨勫仴搴疯嚜鎰垮彈瑭﹁€�

銆€銆€B.鍦ㄩ€�(j矛n)琛岀浉灏�(du矛)鐢熺墿鍒╃敤搴﹀拰鐢熺墿绛夋晥鎬х爺绌舵檪(sh铆)鎳�(y墨ng)棣栧厛閬告搰鍦�(gu贸)鍏�(n猫i)澶栧凡涓婂競鐩稿悓鍔戝瀷鐨勫競鍫�(ch菐ng)涓诲皫(d菐o)鍒跺姂鐐烘(bi膩o)婧�(zh菙n)鍙冩瘮鍒跺姂

銆€銆€C.閲囩敤闆欏懆鏈熶氦鍙夐毃姗�(j墨)瑭﹂(y脿n)瑷�(sh猫)瑷�(j矛)锛屽叐鍊�(g猫)瑭﹂(y脿n)鍛ㄦ湡涔嬮枔鐨勬檪(sh铆)闁撻枔闅斾笉鎳�(y墨ng)灏戜簬钘ョ墿鐨�10鍊�(g猫)鍗婅“鏈�

銆€銆€D.鏁村€�(g猫)閲囨ǎ鏈熸檪(sh铆)闁撹嚦灏戞噳(y墨ng)鐐�3锝�5鍊�(g猫)鍗婅“鏈熸垨閲囨ǎ鎸佺簩(x霉)鍒拌钘ユ績搴︾偤Cmax鐨�1/10锝�1/20

銆€銆€E.鏈嶈棩鍔戦噺涓€鑸噳(y墨ng)鑸囪嚚搴婄敤钘ヤ竴鑷达紝鍙楄│鍒跺姂鍜屽弮姣斿埗鍔戞渶濂界偤绛夊姂閲�

銆€銆€銆愭纰虹瓟妗堛€慉

绶ㄨ集鎺ㄨ枽锛�

2015鍩�(zh铆)妤�(y猫)钘ュ斧鑰冭│鐢ㄦ浉(sh奴)鍚勭鏁欐潗璁婂寲瑙ｆ瀽鍖附

2015鍩�(zh铆)妤�(y猫)钘ュ斧鑰冭│澶х侗鍖附锛堟柊鐗堬級

2015鍩�(zh铆)妤�(y猫)钘ュ斧鑰冭│鑰冪侗璁婂寲瑙ｈ畝

2014鍩�(zh铆)妤�(y猫)钘ュ斧鑰冭│涓棩瀛�(xu茅)缍滃悎鐭ヨ瓨(sh铆)鑸囨妧鑳借€冭│鐪熼

銆婁腑鍦�(gu贸)鍩�(zh铆)妤�(y猫)钘ュ斧銆嬮洔蹇�锛屾帹钖﹁硣鏂欏尟绺�

鐠�(hu谩n)鐞冪恫(w菐ng)鏍￠啱(y墨)瀛�(xu茅)鑰冭│缍�(w菐ng)鍙嬫儏鎻愮ず锛氬鏋滄偍鍦ㄦ閬�(gu貌)绋嬩腑閬囧埌浠讳綍鐤戝晱(w猫n)锛岃珛(q菒ng)鐧婚寗鐠�(hu谩n)鐞冪恫(w菐ng)鏍￠啱(y墨)瀛�(xu茅)鑰冭│璜栧锛岄毃鏅�(sh铆)鑸囧唬澶ц€冪敓鏈嬪弸鍊戜竴璧蜂氦娴�!