2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│寰�(f霉)缈�(x铆)閲嶉粸瑁�(b菙)楂旂郴绲�(t菕ng)鐨勬縺娲昏鎲跺彛瑷閱�(y墨)瀛�(xu茅)鍏嶇柅瀛�(xu茅)鑰冮粸
鐎忚
鏀惰棌
銆€銆€鏂颁竴杓嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│閫�(j矛n)鍏ュ京(f霉)缈�(x铆)閫�(j矛n)绋�锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍℃彁渚�2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│寰�(f霉)缈�(x铆)閲嶉粸瑁�(b菙)楂旂郴绲�(t菕ng)鐨勬縺娲昏鎲跺彛瑷閱�(y墨)瀛�(xu茅)鍏嶇柅瀛�(xu茅)鑰冮粸锛屽笇鏈涘皪澶у鏈夊公鍔�銆傛洿澶氬収(n猫i)瀹规暚璜嬮棞(gu膩n)娉ㄧ挵(hu谩n)鐞冪恫(w菐ng)鏍¤嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│闋婚亾锛屾垜鍊戞渻绔獱鎻愪緵鏇村鏈夊児鍊肩殑鑰冭│鍕曟厠(t脿i)鍙婂京(f霉)缈�(x铆)璩囨枡銆�
銆€銆€鐩搁棞(gu膩n)鎺ㄨ枽锛�鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│绮鹃伕鍌欒€冪稉(j墨ng)椹楀尟绺�
銆€銆€閱�(y墨)瀛�(xu茅)鍏嶇柅瀛�(xu茅)灏嶄簬鑷ㄥ簥閱�(y墨)甯€冭│鐨勮€冪敓渚嗚瑳鍙兘姣旇純闋柤锛屽洜鐐哄ぇ閲忕殑绗﹁櫉寰堥洠瑷樻喍锛屼絾鏄偤浜嗘垜鍊戣兘澶犻爢鍒╅€氶亷鑰冭│锛屾垜鍊戦倓鏄鎺屾彙蹇呴渶鐨勯噸榛炵珷绡€(ji茅)鑸�?锛熻淳顎禦榛烇紝瑁�(b菙)楂旂郴绲�(t菕ng)鐨勬縺娲绘槸閱�(y墨)瀛�(xu茅)鍏嶇柅瀛�(xu茅)涓殑閲嶉粸锛岃€屼笖鏄嚭椤�?锛熼敭c銆�
銆€銆€閱�(y墨)瀛�(xu茅)鍏嶇柅瀛�(xu茅)鑰冮粸瑁�(b菙)楂旂郴绲�(t菕ng)鐨勬縺娲昏鎲跺彛瑷ｏ細鏇夸唬缇庡钃蛋缍�(j墨ng)鍏搁€斿緫銆�
銆€銆€鍙ｈǎ鐨勬剰鎬濇槸锛氳(b菙)楂旀縺娲讳竴鍏辨湁涓夌ó閫斿緫锛屾浛浠�(鏇夸唬閫斿緫)缇庡钃�(MBL)璧扮稉(j墨ng)鍏搁€斿緫(涔熷氨鏄寚缍�(j墨ng)鍏搁€斿緫)锛岀啊鍠殑涓€鍙ュ彛瑷�锛屽嵆鍙浣忎笁绋€斿緫銆傞噸榛為渶瑕佹帉鎻＄殑鏄瘡绋€斿緫鐨勬縺娲荤墿C3銆丆5杞�(zhu菐n)鍖栭叾閮ㄥ垎鐨勭煡璀橀粸銆�
銆€銆€鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│鏁欐潗灏嶆噳(y墨ng)鍏�(n猫i)瀹癸細瑁�(b菙)楂旂郴绲�(t菕ng)鐨勬縺娲婚€斿緫
銆€銆€(涓€)缍�(j墨ng)鍏告縺娲婚€斿緫
銆€銆€鎶楀師-鎶楅珨寰�(f霉)鍚堢墿鑸嘋1q绲�(ji茅)鍚�锛岄爢搴忔椿鍖朇1r銆丆1s銆丆2銆丆4銆丆3锛屽舰鎴怌3杞�(zhu菐n)鍖栭叾(C4b2a)鑸嘋5杞�(zhu菐n)鍖栭叾(C4b2a3b)鐨勭礆鑱�(li谩n)閰朵績鍙嶆噳(y墨ng)閬庣▼鐐鸿(b菙)楂旀縺娲荤殑缍�(j墨ng)鍏搁€斿緫(classical pathway)銆�
銆€銆€1.婵€娲荤墿锛氱敱IgG鎴朓gM绲�(ji茅)鍚堣啘鍨嬫姉鍘熸垨娓搁洟鎶楀師鎵€褰㈡垚鐨勫厤鐤京(f霉)鍚堢墿(1C)銆�
銆€銆€2.娲诲寲閬庣▼锛欼gG鍜孖gM鑸囨姉鍘熺祼(ji茅)鍚堝悗灏�(d菐o)鑷村叾Fc娈电殑瑁�(b菙)楂擟lq绲�(ji茅)鍚堥粸鏆撮湶銆侰lq鑸�2鍊嬩互涓奆c娈电祼(ji茅)鍚堝悗渚濇娲诲寲C1r銆丆1s锛岄€�(j矛n)鑰屽皣C4瑁傝В鐐篊4a鍜孋4b.C2鑸囧浐鐩窩4b绲�(ji茅)鍚�锛岃€屽悗琚獵ls瑁傝В鐐篊2a鍜孋2b锛氬舰鎴愬叿鏈塁3杞�(zhu菐n)鍖栭叾娲绘€х殑C4b2a寰�(f霉)鍚堢墿;瑭插京(f霉)鍚堢墿浣緾3瑁傝В鐐篊3a鍜孋3b锛屽舰鎴怌4b2a3b鍗矯5杞�(zhu菐n)鍖栭叾锛岀辜鑰屽暉鍕曡啘鏀绘搳闅庢銆�
銆€銆€3.鑶滄敾鎿婇殠娈碉細C5杞�(zhu菐n)鍖栭叾灏嘋5瑁傝ВC5a鍜孋5b锛孋5b鍦ㄦ恫鐩镐腑鑸嘋6銆丆7绲�(ji茅)鍚堝舰鎴怌5b67寰�(f霉)鍚堢墿锛屽祵鍏ョ窗(x矛)鑳炶啘鐤忔按鑴傝唱(zh矛)灞や腑锛岄€�(j矛n)鑰岃垏C8銆佽嫢骞睠9鍒嗗瓙鑱氬悎锛屽舰鎴怌5b6789n寰�(f霉)鍚堢墿锛屽嵆鏀昏啘寰�(f霉)鍚堢墿(membrane attack complex锛孧AC)锛屽舰鎴愮┛鑶滅殑瑕按鎬у瓟閬�锛屽皫(d菐o)鑷寸窗(x矛)鑳炲穿瑙ｃ€�
銆€銆€(浜�)鏃佽矾(鏇夸唬)婵€娲婚€斿緫
銆€銆€涓嶄緷璩翠簬鎶楅珨锛岃€岀敱寰敓鐗╃瓑鍦˙鍥犲瓙銆丏鍥犲瓙鍜屽倷瑙ｇ礌鍙冭垏涓嬬洿鎺ユ縺娲籆3锛屽舰鎴怌3杞�(zhu菐n)鍖栭叾鍟熷嫊瑁�(b菙)楂旀縺娲荤殑閬庣▼鐐烘浛浠ｉ€斿緫(alterative pathway)銆�
銆€銆€1.婵€娲荤墿锛氭煇浜涚窗(x矛)鑿屻€佸収(n猫i)姣掔礌銆侀叺姣嶅绯�銆佽憽鑱氱硸鍜屾煇浜涘彲鎺ヨЦ琛ㄩ潰銆�
銆€銆€2.娲诲寲鍟熷嫊閬庣▼锛欳3鍒嗗瓙鑷櫦(f膩)瑁傝В褰㈡垚C3b鍚庤垏B鍥犲瓙绲�(ji茅)鍚�锛屽叾涓瑽鍥犲瓙琚獶鍥犲瓙瑁傝В鐐築b鍜孊a锛孋3bBb妲�(g貌u)鎴愭梺璺€斿緫鐨勮捣濮婥3杞�(zhu菐n)鍖栭叾;鍏朵腑Bb鐗囨鍏风挡姘ㄩ吀铔嬬櫧閰舵椿鎬�锛屽彲瑁傝В鑻ュ共C3鍒嗗瓙鐢熸垚C3b.
銆€銆€鐠�(hu谩n)鐞冪恫(w菐ng)鏍″弸鎯呮彁渚涳細鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│璜栧锛岄毃鏅傝垏寤ｅぇ鑰冪敓鏈嬪弸鍊戜竴璧蜂氦娴�!
绶ㄨ集鎺ㄨ枽锛�
2017骞磋嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│鐢ㄦ浉|鏁欐潗璁婂寲鎯呮硜鍖附
2017骞磋嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│澶х侗鍖附
銆€銆€鏂颁竴杓嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│閫�(j矛n)鍏ュ京(f霉)缈�(x铆)閫�(j矛n)绋�锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍℃彁渚�2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│寰�(f霉)缈�(x铆)閲嶉粸瑁�(b菙)楂旂郴绲�(t菕ng)鐨勬縺娲昏鎲跺彛瑷閱�(y墨)瀛�(xu茅)鍏嶇柅瀛�(xu茅)鑰冮粸锛屽笇鏈涘皪澶у鏈夊公鍔�銆傛洿澶氬収(n猫i)瀹规暚璜嬮棞(gu膩n)娉ㄧ挵(hu谩n)鐞冪恫(w菐ng)鏍¤嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│闋婚亾锛屾垜鍊戞渻绔獱鎻愪緵鏇村鏈夊児鍊肩殑鑰冭│鍕曟厠(t脿i)鍙婂京(f霉)缈�(x铆)璩囨枡銆�
銆€銆€鐩搁棞(gu膩n)鎺ㄨ枽锛�鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│绮鹃伕鍌欒€冪稉(j墨ng)椹楀尟绺�
銆€銆€3.C5杞�(zhu菐n)鍖栭叾鐨勫舰鎴愶細C3b鑸囬檮杩戠殑鑶滆〃闈㈢祼(ji茅)妲�(g貌u)鍏卞児绲�(ji茅)鍚�锛岀祼(ji茅)鍚堜簬鑷韩绲勭箶绱�(x矛)鑳炶〃闈㈢殑C3b鍙澶氱ó瑾�(di脿o)绡€(ji茅)铔嬬櫧(濡侶鍥犲瓙銆両鍥犲瓙銆丏AF銆丮CP銆丆R1绛�)闄嶈В銆佹粎娲�;鑰岀祼(ji茅)鍚堜簬“绱�(x矛)鑿屾縺娲荤墿”琛ㄩ潰鐨凜3b鑸嘊鍥犲瓙绲�(ji茅)鍚堬紝鍥虹浉B鍥犲瓙琚獶鍥犲瓙瑁傝В鐐築b锛屽舰鎴怌3bBb(鏃佽矾閫斿緫C3杞�(zhu菐n)鍖栭叾)銆傚倷瑙ｇ礌(P)鑸嘋3b鍜孊b鍒嗗瓙绲�(ji茅)鍚堝彲绌�(w臎n)瀹氳綁(zhu菐n)鍖栭叾銆傞儴鍒咰3b鑸嘋3bBb寰�(f霉)鍚堢墿绲�(ji茅)鍚堢偤C3bBb3b(鏃佽矾閫斿緫C5杞�(zhu菐n)鍖栭叾)銆傚叾鍚庣殑鑶滄敾鎿婇亷绋嬭垏缍�(j墨ng)鍏搁€斿緫瀹屽叏鐩稿悓銆�
銆€銆€(涓�)鍑濋泦绱�(MBL)婵€娲婚€斿緫
銆€銆€琛€婕夸腑鐨勫嚌闆嗙礌(mannose-bindinglectin锛孧BL)鍒嗗瓙鑳藉鐩存帴绲�(ji茅)鍚�(璀樺垾)澶氱ó鐥呭師寰敓鐗╄〃闈㈢殑N姘ㄥ熀鍗婁钩绯栨垨鐢橀湶绯栵紝閫�(j矛n)鑰屼緷娆℃椿鍖朚ASP1銆丮ASP2銆丆4銆丆2銆丆3锛屽舰鎴愯垏缍�(j墨ng)鍏搁€斿緫涓浉鍚岀殑C3杞�(zhu菐n)鍖栭叾鑸嘋5杞�(zhu菐n)鍖栭叾鐨勭礆鑱�(li谩n)閰朵績鍙嶆噳(y墨ng)閬庣▼鐐鸿(b菙)楂旀椿鍖栫殑鍑濋泦绱犻€斿緫(MBL pathway)銆�
銆€銆€1.婵€娲荤墿锛氬惈N姘ㄥ熀鍗婁钩绯栨垨鐢橀湶绯栧熀鐨勭梾鍘熷井鐢熺墿銆�
銆€銆€2.娲诲寲閬庣▼锛歁BL鑸囧绋梾鍘熷井鐢熺墿琛ㄩ潰鐨凬姘ㄥ熀鍗婁钩绯栨垨鐢橀湶绯栫祼(ji茅)鍚堬紝鐧�(f膩)鐢熸(g貌u)鍨嬫敼璁�锛屽皫(d菐o)鑷碝BL鐩搁棞(gu膩n)鐨勭挡姘ㄩ吀铔嬬櫧閰�(MBL associated serine protease锛孧ASP)娲诲寲锛氣憼娲诲寲鐨凪ASP2鑳戒互椤炰技浜嶤ls鐨勬柟寮忚瑙4鍜孋2锛岀敓鎴愰浼肩稉(j墨ng)鍏搁€斿緫鐨凜3杞�(zhu菐n)鍖栭叾C4b2a;鈶℃椿鍖栫殑MASP1鑳界洿鎺ヨ瑙3鐢熸垚C3b锛屽舰鎴愭梺璺€斿緫C3杞�(zhu菐n)鍖栭叾C3bBb.MBL閫斿緫灏嶈(b菙)楂旂稉(j墨ng)鍏搁€斿緫鍜屾梺璺€斿緫娲诲寲鍏锋湁浜ゅ弶淇冮€�(j矛n)浣滅敤銆�
銆€銆€鐠�(hu谩n)鐞冪恫(w菐ng)鏍″弸鎯呮彁渚涳細鑷ㄥ簥鍩�(zh铆)妤�(y猫)閱�(y墨)甯€冭│璜栧锛岄毃鏅傝垏寤ｅぇ鑰冪敓鏈嬪弸鍊戜竴璧蜂氦娴�!
绶ㄨ集鎺ㄨ枽锛�
2017骞磋嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│鐢ㄦ浉|鏁欐潗璁婂寲鎯呮硜鍖附
2017骞磋嚚搴婂煼(zh铆)妤�(y猫)閱�(y墨)甯€冭│澶х侗鍖附
鏈€鏂拌硣瑷�
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