銆€銆€绗叚璎� 涓昏绲勭箶鐩稿鎬у京(f霉)鍚堥珨鍙婂叾绶ㄧ⒓鍒嗗瓙

銆€銆€涓昏绲勭箶鐩稿鎬у京(f霉)鍚堥珨(major histocompatibility complex, MHC)鏄竴寰�(f霉)闆滅殑鍩哄洜缇�锛屽叾绶ㄧ⒓鐨勭敘(ch菐n)鐗╃ū MHC 鍒嗗瓙锛岀敓鐗╁(xu茅)鍔熻兘鏄彁鍛堟姉鍘熻偨锛岃(di脿o)鎺у厤鐤噳(y墨ng)绛�锛屽湪鐗圭暟鎬у厤鐤噳(y墨ng)绛� 涓捣閲嶈浣滅敤銆傚皬榧� MHC 绋辩偤 H-2 鍩哄洜(寰�(f霉)鍚堥珨);浜虹殑 MHC 绋辩偤 HLA 鍩哄洜(寰�(f霉)鍚堥珨)锛� 鍏剁敘(ch菐n)鐗╃ū鐐� HLA 鍒嗗瓙鎴� HLA 鎶楀師銆�

銆€銆€涓€. MHC 绲�(ji茅)妲�(g貌u)鍙婂叾澶氬熀鍥犵壒鎬�

銆€銆€MHC 鐢扁厾椤�銆佲叀椤炲拰鈪㈤鍩哄洜绲勬垚锛屽叿鏈夊鍩哄洜鐗规€�銆�

銆€銆€1. 缍�(j墨ng)鍏哥殑 MHC鈪犻鍜屸叀椤炲熀鍥�

銆€銆€缍�(j墨ng)鍏哥殑 HLA鈪犻鍩哄洜(HLA鈪燼 鍩哄洜)鍖呮嫭 A銆丅銆丆 涓夊€嬪熀鍥犲骇浣�;缍�(j墨ng)鍏哥殑 HLA

銆€?銆佽澗鎯㈩媰铏弸?DP銆丏Q 鍜� DR 涓夊€嬩簽鍗€(q奴)銆�

銆€銆€2. 鍏嶇柅鍔熻兘鐩搁棞(gu膩n)鍩哄洜杞�(zhu菐n)鑷挵(hu谩n) 鐞� 缍�(w菐ng)鏍du24ol.com

銆€銆€(1)HLA 鈪㈤鍩哄洜 绶ㄧ⒓瑁滈珨鎴愪唤銆�

銆€銆€(2)鎶楀師鍔犲伐銆佹彁鍛堢浉闂�(gu膩n)鍩哄洜(浣嶄簬 HLA II 椤炲熀鍥犲崁(q奴))

銆€銆€a. LMP 鍩哄洜

銆€銆€b. TAP 鍩哄洜

銆€銆€c. HLA-DM 鍩哄洜

銆€銆€d. HLA-DO 鍩哄洜

銆€銆€e. TAP 鐩搁棞(gu膩n)铔嬬櫧鍩哄洜

銆€銆€3. 闈炵稉(j墨ng)鍏糕厾椤炲熀鍥�(HLA I b 鍩哄洜)

銆€銆€(1)HLA-E 鍩哄洜

銆€銆€(2)HLA-G 鍩哄洜

銆€銆€4. 鐐庣櫏鐩搁棞(gu膩n)鍩哄洜(浣嶄簬 HLA 鈪㈤鍩哄洜鍗€(q奴))

銆€銆€(1)TNF 鍩哄洜

銆€銆€(2)杞�(zhu菐n)閷勮(di脿o)绡€(ji茅)鍩哄洜杞�(zhu菐n)鑷挵(hu谩n) 鐞� 缍�(w菐ng)鏍du24ol.com

銆€銆€(3)MHC鈪犻鐩搁棞(gu膩n)鍩哄洜(MIC)

銆€銆€(4)HSP 鍩哄洜

銆€銆€浜�. MHC 鐨勫鎱�(t脿i)鎬�

銆€銆€1. 澶氭厠(t脿i)鎬� 鎸囦竴鍊嬪熀鍥犲骇浣嶄笂瀛樺湪澶氬€嬬瓑浣嶅熀鍥�銆�

銆€銆€2. HLA 澶氭厠(t脿i)鎬х殑鐢�(ch菐n)鐢熷強鐢熺墿瀛�(xu茅)鎰忕京 澶氭厠(t脿i)鎬х殑鐢�(ch菐n)鐢燂細鑷劧閬告搰(閬告搰澹撳姏) 鐢熺墿瀛�(xu茅)鎰忕京锛氱兢楂旀按骞充笂璩︿簣浜洪鐨勭敓瀛樺劒(y艒u)鍕�銆�

銆€銆€涓�. 浜虹殑 HLA 鍒嗗瓙

銆€銆€1. 缍�(j墨ng)鍏哥殑 HLA鈪犻鍒嗗瓙

銆€銆€鐢� α 閺�(鍚� α1銆�α2 鍜� α3 涓夊€嬬祼(ji茅)妲�(g貌u)鍩�)鍜� β 閺�(β2m,鐢变汉鐨� 15 铏熸煋鑹查珨绶ㄧ⒓)绲勬垚;鍏朵腑 α1 鍜� α2 妲�(g貌u)鎴愨厾椤炲垎瀛愭姉鍘熺祼(ji茅)鍚堟Ы銆傘€�

銆€銆€2. 缍�(j墨ng)鍏哥殑 HLA鈪￠鍒嗗瓙

銆€銆€鐢� α 閺�(鍚� α1銆�α2 绲�(ji茅)妲�(g貌u)鍩�)鍜� β 閺�(鍚� β1 鍜� β2 绲�(ji茅)妲�(g貌u)鍩熺祫鎴�);鍏朵腑 α1銆�β1 妲�(g貌u)鎴愨叀 椤炲垎瀛愮殑鎶楀師绲�(ji茅)鍚堟Ы銆�

銆€銆€鍥�.MHC 鍒嗗瓙鍜屾姉鍘熻偨鐨勭浉浜掍綔鐢�杞�(zhu菐n)鑷挵(hu谩n) 鐞� 缍�(w菐ng)鏍du24ol.com

銆€銆€1. 鍒嗗瓙鍩虹(ch菙) 閷ㄥ畾浣� 閷ㄥ畾娈樺熀 鍏卞悓鍩哄簭

銆€銆€2. 鐗归粸 灏堜竴鎬ц垏鍖呭鎬�銆�

銆€銆€浜�.MHC 鐨勭敓鐗╁(xu茅)鍔熻兘

銆€銆€1. 鎻愬憟鎶楀師銆佸弮鑸囬仼鎳�(y墨ng)鎬у厤鐤噳(y墨ng)绛�

銆€銆€(1)鎻愬憟鎶楀師渚� T 绱拌優璀樺垾锛屽暉鍕曠壒鐣版€у厤鐤噳(y墨ng)绛�

銆€銆€(2)浠嬪皫(d菐o) T 绱拌優鍦ㄨ兏鑵轰腑鐨勫垎鍖�銆佹垚鐔熴€�

銆€銆€(3)鐤剧梾鏄撴劅鎬у€嬮珨鐨勪富瑕佹焙瀹氳€�

銆€銆€(4)瑾�(di脿o)鎺ф楂斿厤鐤姛鑳�

銆€銆€2. 鍙冭垏鍥烘湁鍏嶇柅鎳�(y墨ng)绛�

銆€銆€MHC 鍏嶇柅鍔熻兘鐩搁棞(gu膩n)鍩哄洜鍙冭垏灏嶉潪鐗圭暟鎬у厤鐤噳(y墨ng)绛旂殑瑾�(di脿o)鎺у叚.HLA 鑸囪嚚搴婇啱(y墨)瀛�(xu茅)

銆€銆€1. HLA 鑸囧櫒瀹樼Щ妞嶏細

銆€銆€2. HLA 鐣板父琛ㄩ仈鍜岃嚚搴婄柧鐥�杞�(zhu菐n)鑷挵(hu谩n) 鐞� 缍�(w菐ng)鏍du24ol.com

銆€銆€3. HLA 鑸囩柧鐥呴棞(gu膩n)鑱�(li谩n)

銆€銆€4. HLA 鑸囪Κ瀛愰憭瀹氬拰娉曢啱(y墨)瀛�(xu茅)

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