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銆€銆€钘ョ墿鐨勯噺鏁堥棞(gu膩n)绯� 鍦ㄤ竴瀹氬姂閲忚寖鍦嶅収(n猫i)锛岃棩鐗╁姂閲忕殑澶у皬鑸囪钘ユ績搴︾殑楂樹綆鎴愭姣�锛屼害鑸囪棩鏁堢殑寮�(qi谩ng)寮辨湁闂�(gu膩n)銆傚嵆琛€钘ユ績搴﹂珮浣庤垏钘ユ晥鐨勫挤(qi谩ng)寮辨湁闂�(gu膩n)锛岄€欑ó鍔戦噺鑸囨晥鎳�(y墨ng)鐨勯棞(gu膩n)绯荤ū閲忔晥闂�(gu膩n)绯�銆傞噺鏁堥棞(gu膩n)绯诲彲鐢ㄩ噺—鏁堟洸绶氳〃绀�銆傜敤钘ョ殑鍔戦噺澶皬寰€寰€鐒℃晥锛屽姂閲忓お澶у張鏈冨嚭鐝�(xi脿n)涓瘨鐧ョ媭銆傞€氶亷閲忔晥闂�(gu膩n)绯荤殑鐮旂┒锛屽彲瀹氶噺鍦板垎鏋愯棩鐗╁姂閲忚垏鏁堟噳(y墨ng)涔嬮枔鐨勮(gu墨)寰�锛屾湁鍔╀簬浜嗚В钘ョ墿浣滅敤鐨勬€ц唱(zh矛)锛屼篃鍙偤鑷ㄥ簥鐢ㄨ棩鎻愪緵鍙冭€�銆�

銆€銆€(1)鏈€灏忔湁鏁堥噺鍜屾渶灏忎腑姣掗噺锛氳兘寮曡捣钘ョ悊鏁堟噳(y墨ng)鐨勬渶灏忓姂閲�(鎴栨渶灏忔績搴�)绋辨渶灏忔湁鏁堥噺鎴栭柧鍔戦噺銆傚嚭鐝�(xi脿n)涓瘨鐧ョ媭鐨勬渶灏忓姂閲忕ū鏈€灏忎腑姣掗噺銆傞毃钁楀姂閲忕殑澧炲姞锛屾晥鎳�(y墨ng)涔熺浉鎳�(y墨ng)鍔犲ぇ锛岀洿鍒板嚭鐝�(xi脿n)鏈€澶ф晥鎳�(y墨ng)銆備互鍚�锛岃嫢鍐嶅鍔犲姂閲忓苟涓嶈兘浣挎晥鎳�(y墨ng)閫�(j矛n)涓€姝ュ鍔�锛屽弽鑰屾渻鍑虹従(xi脿n)姣掓€у弽鎳�(y墨ng)銆傚嚭鐝�(xi脿n)鐧傛晥鐨勬渶澶у姂閲忕ū妤甸噺锛屾槸瀹夊叏鐢ㄨ棩鐨勬渶澶ч檺搴�銆�

銆€銆€(2)閲忓弽鎳�(y墨ng)鍜岃唱(zh矛)鍙嶆噳(y墨ng)

銆€銆€1)閲忓弽鎳�(y墨ng)锛氳棩鐞嗘晥鎳�(y墨ng)鐨勯珮浣庢垨澶氬皯锛屽彲鐢ㄦ暩(sh霉)瀛楁垨閲忕殑鍒嗙礆琛ㄧず锛屽蹇冪巼銆佽澹撱€佽绯栨績搴�銆佸翱閲�銆佸钩婊戣倢鏀剁府鎴栨澗寮涚殑绋嬪害绛�锛岄€欑ó鍙嶆噳(y墨ng)椤炲瀷绋遍噺鍙嶆噳(y墨ng)銆�

銆€銆€a.鍗婃暩(sh霉)鏈夋晥閲�(ED50)锛氶噺鍙嶆噳(y墨ng)鐨凟D50鎸囨(bi膩o)鏄寚閬�(d谩)鏈€澶ф晥鎳�(y墨ng)涓€鍗婃墍鐢ㄧ殑钘ョ墿鍔戦噺銆傚湪S褰㈡洸绶氫腑锛岀偤50%鏁堟噳(y墨ng)铏曟墍灏嶆噳(y墨ng)鐨勫姂閲忥紝姝よ檿鏂滅巼鏈€澶�锛岀祼(ji茅)鏋滄瘮杓冪簿纰哄彲闈犮€�

銆€銆€b.钘ョ墿鐨勬晥鍍�(ji脿)寮�(qi谩ng)搴︼細鏄寚浣滅敤鎬ц唱(zh矛)鐩稿悓鐨勮棩鐗╃敘(ch菐n)鐢熺浉绛夋晥鎳�(y墨ng)鏅�(sh铆)钘ョ墿鍔戦噺鐨勫樊鍒�;

銆€銆€c. 钘ョ墿鐨勬晥鑳斤細鎸囪棩鐗╂墍鑳界敘(ch菐n)鐢熺殑鏈€澶ф晥鎳�(y墨ng)銆�

銆€銆€2) 璩�(zh矛)鍙嶆噳(y墨ng)锛氳瀵熺殑钘ョ悊鏁堟噳(y墨ng)鏄敤闄芥€ф垨闄版€т締琛ㄧず銆�

銆€銆€a.鍗婃暩(sh霉)鏈夋晥閲忥細鎸囧崐鏁�(sh霉)瀵�(sh铆)椹�(y脿n)鍕曠墿鍑虹従(xi脿n)闄芥€у弽鎳�(y墨ng)鐨勮棩鐗╁姂閲�銆傛敞鎰忚唱(zh矛)鍙嶆噳(y墨ng)鍜岄噺鍙嶆噳(y墨ng)鐨勫崐鏁�(sh霉)鏈夋晥閲忕殑姒傚康涓嶅悓銆�

銆€銆€b.鍗婃暩(sh霉)鑷存閲忥細鎸囧崐鏁�(sh霉)瀵�(sh铆)椹�(y脿n)鍕曠墿姝讳骸鐨勮棩鐗╁姂閲�銆�

銆€銆€c.娌荤檪鎸囨暩(sh霉)(TI)锛氱敤LD50/ED50琛ㄧず銆傚彲鐢═I渚嗕及瑷�(j矛)钘ョ墿鐨勫畨鍏ㄦ€�锛屾鏁�(sh霉)鍊艰秺澶ц〃绀鸿棩鐗╄秺瀹夊叏銆�

銆€銆€d.瀹夊叏鎸囨暩(sh霉)锛氱敤LD5/ED95琛ㄧず銆�

銆€銆€e. 瀹夊叏鐣岄檺锛氱敤(LDl—ED99)/ED99锛岃〃绀恒€�

銆€銆€娌荤檪鎸囨暩(sh霉)鏈€冩叜鍒拌棩鐗╂渶澶ф湁鏁堥噺鏅�(sh铆)鐨勬瘨鎬�锛屼互鍚庡叐鑰�(瀹夊叏鎸囨暩(sh霉)鍜屽畨鍏ㄧ晫闄�)瑭曞児(ji脿)钘ョ墿鐨勫畨鍏ㄦ€э紝姣旂敤娌荤檪鎸囨暩(sh霉)瑭曞児(ji脿)鏇寸偤鍙潬銆�

銆€銆€f.瀹夊叏鑼冨湇锛氬湪鑷ㄥ簥涓�锛屾湁鏅�(sh铆)涔熺敤钘ョ墿鐨勬渶灏忔湁鏁堥噺鍜屾渶灏忎腑姣掗噺涔嬮枔鐨勮窛闆㈣〃绀鸿棩鐗╃殑瀹夊叏鎬э紝绋卞畨鍏ㄨ寖鍦�銆傚叾璺濋洟鎰堝ぇ鎰堝畨鍏紝浣嗙偤浜嗕繚璀夎嚚搴婄敤钘ョ殑瀹夊叏锛岄伕鐢ㄨ棩鐗╂檪(sh铆)蹇呴爤涓€骞惰€冩叜鍏舵不鐧傛寚鏁�(sh霉)鎴栧畨鍏ㄨ寖鍦嶅€肩殑澶у皬銆�

• 2010骞磋棩瀛�(xu茅)鑰冭│鎴愮妇鏌ヨ鍦板潃
• 2010琛�(w猫i)鐢熻伔绋辫€冭│鎴愮妇鏌ヨ灏堥
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鏇村淇℃伅瑷晱锛�鍒濈礆钘ュ＋鑰冭│闋婚亾   鍒濈礆钘ュ＋鑰冭│璜栧 琛�(w猫i)鐢熻伔绋卞崥瀹㈠湀